@ Biopharmaceutical startup developing heart failure therapeutic raises more than $28M | SEBIO

Biopharmaceutical startup developing heart failure therapeutic raises more than $28M

Posted by on Nov 8, 2012

CHAPEL HILL, NC – Cardioxyl Pharmaceutical has raised $28.05 million, according to a Form D filing with the Securities and Exchange Commission.  Investors include Aurora Funds and New Enterprise Associates.

The drug development company’s lead product in its pipeline, CXL-1020, is a compound designed to treat acute decompensated heart failure, the top reason for hospitalization among adults aged 65 or older in the US.The condition results in reduced cardiac function that typically results in fluid accumulation in the lungs (a condition called pulmonary edema) and severe shortness of breath, according to the company’s website. The therapeutic in Phase 2 development was licensed from Johns Hopkins University.It is designed to improve the performance of heart muscle contractions and widen the blood vessels to increase blood flow without increasing the heart rate. It also has three other cardiovascular disease therapeutics in preclinical development.

Christopher Kroeger is the CEO. Prior to joining Cardioxyl he led biopharmaceutical and medical device investments at Aurora Funds. John Reardon, the chief scientific officer previously worked at GlaxoSmithKline for 20 years most recently as senior vice president of discovery research biology, a role in which he was responsible for global pre-clinical research activities.  Doug Cowart, a founder of the company, is the executive vice resident of development and regulatory affairs. He previously served as senior director of cardiovascular development at Otsuka Pharmaceuticals.

Acute decompensated heart failure affects about 5 million people. Hospitalizations are a combination of people diagnosed with the condition for the first time and those who suffer from chronic heart failure. It’s a challenging condition for clinicians to treat and has a high mortality rate.



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